Fractionation and Chromatography

Supercritical CO2 extraction, fractionation, chromatography

SFE SFF SFC processus schema

From extraction to chromatography, SFE Process covers the entire process thanks to its supercritical CO2 extraction, fractionation and chromatography equipment.
In a simplified way, the overall process is detailed as follows:
extraction of a solid starting material, fractionation which allows dewaxing and also extraction from a liquid product, and chromatography which allows verification of the purity and composition of the product.


Innovation is part of our DNA

Reliable systems and innovative vision to fit your needs with R&D projects. We are developing innovative products and tailor made equipment.

R&D investigations shows that the development will rocket in the near future.

To fit your needs SFE Process builds ultra-high performance advanced equipment. We are developing R&D projects to go further. To complete the process in order to extract, purify and analyse, it will optimize the process. We design and develop fractionation, impregnation, chromatography, dewaxing, analysis, purification processes and equipment because we anticipate future needs and market evolutions.

We already master all the processes linked with supercritical CO2. We have already manufactured an extraction and fractionation equipment for perfume, cosmetic and aroma laboratories. We also have created a fractionation system for laboratories to extract desired compounds or remove unwanted molecules.

We manufactured a GMP supercritical CO2 fractionation system for glove box and white room, for particules formation.

We are now developing a new project in wider scale to selectively extract and collect desired molecule from liquids thanks to fractionation process in industrial scale.

sff sfc equipment

Supercritical CO2 fractionnation

The objectives of supercritical CO2 fractionation:

This technology is used in the case of complex mixtures that need to be separated and for the removal of molecules of interest or targeted compounds. This process allows extraction from liquids. Supercritical CO2 fractionation is also used for purification purposes and can be processed  after a supercritical CO2 extraction as well as upstream of chromatography.


Advantages of supercritical CO2 fractionation:

Supercritical CO2 fractionation has the advantage of being a green technology, which does not pollute and produces co-products rather than waste.  A notable advantage is that the process respects sensitive products such as thermally sensitive plant compounds etc. Thus it is possible to extract compounds while maintaining their original properties and benefits, as well as to preserve the loaded product. (No alteration of the components and benefits preserved.) Supercritical CO2 fractionation equipment has the advantage of eliminating post-treatment steps and optimizing the continuous extraction process. SFE Process Fractionation equipment can be coupled with SFELab & SFEProd equipment. They allow high efficiency and laboratory precision. SFE Process has developed equipment in automated or manual version, very easy to use to match the needs in R&D and education.


The operation of supercritical CO2 fractionation

The supercritical CO2 is injected  via a counter-current liquid flow into a fractionation column. In the fractionation column, the supercritical CO2 is loaded with desired components, leaving out unwanted molecules. This customization is possible thanks to an orchestration of the fractionation parameters configuring density, diffusion, solvency. By using an extract reflux, the selectivity of the separation is increased.


The Applications

Fractionation is used for cosmetics, chemistry, biological research, research and development in general, food processing, pharmaceuticals, petrochemicals, biofuels, polymers, perfumery.


A few examples:

Supercritical fractionation is used for formulation in the field of cosmetics.


Supercritical fractionation is also used in perfumery for the creation and elaboration of fragrances and perfumes: the olfactory profile obtained is not the same depending on the solvent used for extraction (CO2 / hexane / butane). Discover our article on the use of supercritical CO2 fractionation technology in perfumery.


For the supercritical fractionation of citrus oils and essential oils, allowing to obtain different fractions of extracts and to preserve terpenes without alteration.


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